In other words, replacement of the number 8 carbon by nitrogen in the purine ring does not eliminate activity. 换句话说,嘌呤环上第8位碳被氮所取代并不丧失活性。
The derivative of adding substitution groups in purine ring s 2 or 6 or 8 atoms are important organism medicine activating substances useful as an antiviral, anticancer, and hypotensor drugs. So study of purine derivative has important meaning. 在嘌呤环的2,6或8位碳原子上引入某些取代基团所得的衍生物具有抗病毒、抗癌和降血压等重要的生物医学活性,因此对嘌呤衍生物的研究具有重要意义。
If the 6-C in the ring is replaced by N, the distribution of electron density of purine ring must be changed. 将嘌呤6-位氨基或氧用6-氮杂代替,必将引起嘌呤环电性效应的改变。